Analysis of the results of the agglutination intensity of the direct anti-human globulin test and its clinical significance
Objective:To analyze the factors affecting the agglutination intensity of direct antiglobulin test(DAT)and the relationship between DAT agglutination intensity on total bilirubin(TBil)and lactate dehydrogen-ase(LDH),and to discuss its clinical significance for clinical diagnosis and treatment.Methods:We retrospective-ly analyzed the data of 725 direct anti-positive patients from January 2021 to June 2022 in the First Hospital of Longyan City,the distribution of departments,the relationship between gender,age,transfusion history and the intensity of DAT positivity,and also analyzed the effect of DAT positivity intensity on TBil and LDH.Results:DAT positivity was mainly distributed in internal medicine departments such as hematology,respiratory medicine,and cardiovascular medicine.There was no statistical difference in the distribution of DAT positivity intensity by gender(x2=5.518,P＞0.05).The distribution of DAT positive intensity in the age group≤60 years old and the age group＞60 years old was statistically significant(x2=11.604,P＜0.05).History of blood transfusion was statistically significant in the distribution of DAT positive intensity(x2=48.394,P＜0.05).Both TBil and LDH were significantly stronger in patients with DAT agglutination intensity of 4+than in patients with DAT aggluti-nation intensity of 0.5+-1+and 3+(P＜0.001).Conclusion:DAT-positive hemolysis is seen in departments with hematologic disorders or departments prone to anemia that require more blood transfusions such as hematolo-gy and critical care medicine.Both transfusion history and age can affect DAT agglutination intensity,and there is a correlation between DAT agglutination intensity and TBil and LDH.DAT results have important implications for both clinical diagnosis and transfusion.
direct antiglobulin testagglutination intensitydiagnosishemolysis
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