贫血是系统性红斑狼疮(systemic lupus erythematosus,SLE)患者常见的临床表现之一,见于约50％的SLE患者中.SLE相关性贫血的病因和发病机制主要包括慢性病贫血、缺铁性贫血及自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)等.贫血可以加重SLE病情,AIHA和单纯红细胞再生障碍性贫血(pure red cell aplasia,PRCA)可以使SLE容易复发、难治.SLE相关性贫血的基础治疗包括病因治疗、促红细胞生成素治疗、铁剂治疗及输血治疗等.SLE患者合并AIHA、PRCA时,按原发性AIHA、PRCA治疗,但它们较原发性AIHA、PRCA难治.
Research progress on systemic lupus erythematosus related anemia
Anemia is a common clinical manifestation in patients with systemic lupus erythematosus(SLE),affecting approximately 50％of patients.The etiology and pathogenesis of SLE-associated anemia mainly include anemia of chronic disease,iron deficiency anemia,and autoimmune hemolytic anemia(AIHA).Anemia can exac-erbate the condition of SLE,and AIHA and pure red cell aplasia(PRCA)can render SLE prone to recurrence and challenging to treat.The basic treatment for SLE-associated anemia includes etiological treatment,erythropoiesis-stimulating agent therapy,iron supplementation therapy,and blood transfusion therapy.SLE patients with AIHA and PRCA are treated as primary AIHA and PRCA,but they are more challenging to treat than primary AIHA and PRCA.
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