Changes in microvascular density and nerve fiber layer thickness in optic disc and peridisk in patients with type 2 diabetes observed by OCTA
Objective To observe the changes of blood flow density and nerve fiber layer thickness around optic papilla(ONH)in type 2 diabetes patients by optical coherence tomography angiography(OCTA).Methods It was a cross-sectional study.44 patients with no clinically visible diabetic retinopathy(NDR)and 48 patients with non-proliferative dia-betic retinopathy(NPDR)were enrolled.At the same time,45 healthy subjects were selected as the control group.All sub-jects underwent OCTA to examine the 4.5 mm×4.5 mm blood flow pattern in the optic disc area,and the software automati-cally calculated the peripapillary capillary density and the nerve fiber layer around the papilla in each section(retinal nerve fibre layer,RNFL)thickness.Statistical softwareSPSS 25.0was used to analyze the data.Results The blood flow density of capillaries around the optic nerve papilla and the thickness of nerve fiber layer in the control group,NDR and NPDR groups were compared respectively.1.In the NDR group,radial peripapillary capillaries vascular density(RPCVD)de-creased in(47.88±1.59)%overall,(47.56±1.86)%intra-optic disc and(51.80±1.94)%superior temporal(ST)(P=0.04,0.02,0.007,all P<0.05,respectively).The thickness of RNFL in NDR group was decreased but(P>0.05.2).Compared with the control group,the 48 cases of NPDR group were overall(45.77±2.28)%,intra-optic(44.03±1.58)%,para-optic(47.26±1.48)%,supranasal(NS)(45.90±2.78)%,subnasal(NI)(45.90±2.78)%,inferior nasal(IN)(47.44±2.17)%,infe-rior temporal(IT)(51.75±5.27)%,inferior temporal(TI)(49.38±3.74)%,superior temporal(TS)(53.48±3.32)%,superior temporal(ST)(54.27±3.17)%and upper nasal(SN)(45.47±2.24)%,the peripapillary capillary density was significantly decreased in all areas(P<0.05).The thickness of RNFL IN inferior nasal(IN)(118.7 9±12.23)μm,inferior temporal(IT)(134.81±13.55)μm,inferior nasal(IN)(P=0.023),inferior temporal(IT)(P =0.035)two areas(P<0.05),the thickness of RNFL decreased,the difference was statistically significant.Conclusions Capillary blood flow density in the optic nerve head region may provide evidence that microvasculature has changed before nerve injury in early DR.The reduction of blood perfusion in the optic disc may be one of the important signs of early DR detection.OCTA may be a more promising tool in DR screening in ONH flow patterns.
国家科技期刊平台
NSTL
万方数据
维普
