儿童结膜囊肿11例临床病理分析
Clinical pathological analysis of 11 children with conjunctival cyst
李强 1周春菊 2苏学刚 1崔燕辉 3白大勇3
作者信息
- 1. 101321 北京,顺义妇幼保健院眼科
- 2. 100045 首都医科大学附属北京儿童医院病理科
- 3. 100045 首都医科大学附属北京儿童医院眼科
- 折叠
摘要
目的 探讨儿童结膜囊肿患者的组织病理学特点并探讨发病原因.方法 对11例(12只眼)儿童结膜囊肿手术的患者进行回顾性分析,主要包括年龄、性别、眼部疾病,发病部位、组织病理学特点.结果 11例眼部结膜囊肿患者年龄(79.18±22.77)个月(2岁7个月至10岁7个月),男性8例,女性3例,10例有眼外肌手术史,1例为先天性囊肿.10例行HE染色,PAS染色及免疫组化染色(MUC5AC、CK、D2-40),1例行透射电镜检查.HE染色可见囊肿内壁为扁平上皮或者复层柱状上皮组织,2例与肌肉组织相连.PAS染色,3例弱阳性,2例阳性.免疫组化染色:MUC5AC染色5例弱阳性,1例阳性;CK染色及D2-40染色,10均为强阳性.1例可见淋巴管D2-40染色阳性.结论 儿童结膜囊肿内壁细胞以复层柱状上皮多见,含有少量非典型杯状细胞,与球结膜上皮有相似性,囊肿内淋巴管不多见.囊内液的具体来源尚需进一步的研究才能确定.
Abstract
Objective To study the histopathological characteristics of children with conjunctival cysts and the causes.Methods A retrospective analysis was performed on 11 children with conjunctival cyst who had surgery,whose age,gender,eye diseases,disease sites,and histopathological characteristics were collected.Results Eleven patients with conjunctival cysts(12 eyes),average age of(79.18±22.77)months.There were 8 males and 3 females,10 had a his-tory of extraocular muscle surgery,and 1 was a congenital cyst.Ten patients underwent HE staining,PAS staining and im-munohistochemical staining(MUC5AC,CK,D2-40),and one patient underwent transmission electron microscopy.HE staining showed that the inner wall of the cyst was flat epithelium or stratified epithelial tissue,and 2 cases were connected with muscle tissue.PAS staining was weakly positive in 3 cases and positive in 2 cases.Immunohistochemical staining:MUC5AC staining was weakly positive in 5 cases,and positive in 1 case;CK staining and D2-40 staining were 10,all were strongly positive.Lymphatic vessels with D2-40 staining was found in 1 case.Conclusions The inner wall cells of conjunc-tival cysts in children are more common in stratified columnar epithelium,which contain a small number of atypical goblet cells.They are similar to bulbar conjunctival epithelium,and the lymphatic vessels in cysts are rare.The specific source of the cyst fluid needs further research to determine.
关键词
结膜囊肿/儿童/病理/免疫组化Key words
Conjunctival Cyst/Child/Pathology/Immunohistochemistry引用本文复制引用
基金项目
北京市属医院科研培育计划项目(PX2019047)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据