Observation of retinal blood flow density in patients with moderate to high myopia by global swept ultra-wide-angle OCTA
Objective To assess changes in retinal blood flow density in people with moderate to high myopia us-ing full-field swept-frequency optical coherence tomography angiography(OCTA)(Tupai swept-frequency OCTA).Meth-ods A cross-sectional study.A total of 46 patients(90 eyes)with moderate to high myopia attending Chongqing Aier Eye Hospital from 2022.3.1 to 2022.3.31 were included,and divided into 44 eyes in the moderate myopia group(-3.00D<SE<-6.00 D)and 46 eyes in the high myopia group(SE≥-6.00 D)according to the equivalent spherical lens(SE).The intraocular lens(IOL)Master was used to measure the ocular axis(AL),and the new domestic full-field sweep OCTA(Tupai sweep OCTA)was used to measure the retinal vascular density and other indexes in the posterior pole.5 concentric circles were drawn with 1、3、6、9and 12 mm diameters,centered on the central macular recess,and divided into 1、2、3、4and 5 rings,and the retinal blood flow density was calculated for each ring separately.A comparison of superficial retinal blood flow density between the two groups was performed by independent sample t-test.Correlation between AL and superficial retinal vascular density(SCPVD),central macular concave thickness(CRT),and foveal avascular zone(FAZ)area were analyzed by Pearson or Spearman correlation.Results A total of 46 cases(90 eyes)were included,44 eyes with moderate myopia,24 males and 20 females,age(30.73±4.27)years,and eye axis(24.94±1.24)mm.46 eyes with high myopia,27 males and 19 females,age(32.11±8.38)years,and eye axis(26.30±1.35)mm.Statistical analysis was performed on the data of both groups.There was a statistically significant difference in 2、3、and 4 ring SCPVD between the two groups(P= 0.007;P<0.001;P<0.001),and no statistical difference in 1 and 5 ring SCPVD,FAZ,and CRT between the two groups(P=0.344,0.062,0.079,and 0.553).There was a negative correlation between AL and SCPVD(All P<0.05),no correla-tion between AL and CRT and FAZ(P>0.05).No correlation between CRT and each ring SCPVD and FAZ(all P>0.05).Conclusions Retinal blood flow density was lower in patients with high myopia thanin those with moderate myopia.AL was negatively correlated with superficial retinal blood flow density and not with CRT or FAZ.There was no correlation be-tween CRT and superficial retinal blood flow density or FAZ.
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