Clinical study on the relationship between serum YKL-40、TNF-α and diabetic retinopathy
Objective To study human cartilage glycoprotein-39(YKL-40)and tumor necrosis factor-α(TNF-α)in serum correlation with diabetes retinopathy(DR)and clinical indicators.To discuss YKL-40 and TNF-α the role played in the occurrence and development of DR was expected to be used for screening,prediction,and diagnosis of high-risk groups of diabetes retinopathy.Methods A retrospective case series study.The patients with simple type 2 diabetes ignor-ing retinopathy(DM group),the patients with non proliferative diabetes retinopathy(NPDR group),the patients with prolif-erative diabetes retinopathy(PDR group),and the patients who underwent cataract surgery at the same time were selected as the blank control group(NGT group),and the time was selected as the patients hospitalized in our hospital from March 2021 to June 2022.All research subject's basic information,such as gender,age,course of disease,height,weight,systolic blood pressure(SBP),diastolic blood pressure(DBP)and body mass index(BMI)were recorded.The fasting elbow ve-nous blood was drawn to separate the serum.Fasting venous blood glucose(FBG),glycosylated hemoglobin(HbA1c),tri-glyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C),fasting insu-lin(FINS)and other clinical indicators,and calculate insulin resistance index(HOMA-IR).The serum YKL-40 and TNF-α were detected by enzyme-linked immunosorbent assay,and the relationship between them and other clinical indicators was further analyzed.Results The serum YKL-40 concentration in PDR group was(67.93±8.52)ng/mL,which was higher than that in NPDR group(59.29±7.87)ng/mL,DM group(50.08±10.01)ng/mL and NGT group(39.07±9.59)ng/mL,with significant differences(P<0.001).The serum TNF-α concentration of PDR group was(68.35±8.66)pg/mL,which was higher than that of NPDR group(60.59±8.58)pg/mL,DM group(47.02±11.34)pg/mL and NGT group(38.7±8.32)pg/mL(all P<0.001).Serum YKL-40 was positively correlated with course of disease,glycosylated hemoglobin,ve-nous blood glucose and insulin resistance index(P<0.05).Serum TNF-α was positively correlated with the course of dis-ease,glycosylated hemoglobin,venous blood glucose and insulin resistance index(P<0.05).Area under ROC curve of se-rum YKL-40,serum TNF-α and the time of combined diagnosis were 0.894,0.927,and 0.935,respectively.Conclusions The levelsof YKL-40 and TNF-αwere gradually increased in the NC,DM,NPDR and PDR groups,which may be involved in the pathogenesis of DR.The increased levels of YKL-40 and TNF-α may be more dangerous for diabetic patients.
Human cartilage glycoprotein-39Tumor necrosis factor-αDiabetes retinopathy
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