Changes in the morphology and function of the meibomian glands and tear film in pregnant women with hy-perlipidaemia
Objective To investigate the changes of morphology and function of meibomian glands in pregnant women with hyperlipidaemia and their influence on the tear film.Methods A retrospective case series study.A total of 60 pregnant women(120 eyes)admitted to the ophthalmology department of our hospital from January 2020 to January 2022 were selected,and divided into hyperlipidemia group(60 eyes,30 cases)and control group(60 eyes,30 cases)according to whether they were combined with hyperlipidemia.Both groups received ocular surface disease index(OSDI)、meibomian gland function examination,ocular surface examination and blood lipid examination.The differences between the two groups were compared with the morphology and the scores of the function of lid edge and meibomian glands,the scores of fluores-cence staining of cornea,breakup time(BUT)of tear film,Schirmer I test(SIt).The correlation between the scores of BUT and blood lipid level in the hyperlipidemia group was analyzed.Results The scores of OSDI,meibomian gland secretion ability and meibomian gland secretion traits in the hyperlipidemia group were significantly higher than those in the control group(P<0.05).The BUT in the hyperlipidemia group was significantly lower than that in the control group.There were no significant differences in the values of SIt,the scores of eyelid margin change and meibomian gland loss scores between the two groups(P>0.05).Spearman correlation analysis showed that the severity of BUT in the hyperlipidemia group was posi-tively correlated with total cholesterol(TC)、triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)levels(P<0.05).Conclusions Pregnant women with hyperlipidaemia were prone to cause the dysfunction of the meibomian gland se-cretion,which was easy to shorten the stability of the tear film.There was no significant change in tear secretion.The change of BUT was highly correlated with the level of TC,TG and LDL-C in blood lipids.
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