首页|超声乳化联合玻璃体注射抗VEGF药治疗白内障合并黄斑水肿的应用

超声乳化联合玻璃体注射抗VEGF药治疗白内障合并黄斑水肿的应用

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目的 观察白内障超声乳化联合玻璃体腔注射抗血管内皮生长因子(VEGF)药物治疗白内障合并各种黄斑水肿的临床效果.方法 回顾性病例对照研究.选取眼科2019年1月至2022年12月期间眼科住院白内障合并各种黄斑病变(糖尿病性黄斑水肿,年龄相关性黄斑变性),高度近视脉络膜新生血管(CNV)20例(20只眼),随机分成两组,A组(10例)给予白内障超声乳化吸除联合人工晶状体植入术,术中联合玻璃体内抗VEGF药物注射,B组(10例)行白内障超声乳化联合人工晶状体植入术.随访1个月,观察两组之间治疗前后:前房及玻璃体情况、最佳矫正视力(BCVA)、黄斑中心凹厚度(CMT)、眼压的差异.结果 A组术后CMT及眼压较术前降低,和B组比较差异有统计学意义(P<0.05).两组术后BCVA都较术前提高,A组明显好于B组,差异有统计学意义(P<0.05).结论 白内障超声化术联合玻璃体抗VEGF药物,治疗白内障合并黄斑水肿应用安全有效,值得推广.
Application of phacoemulsification combined with vitreous injection of anti-VEGF drugs for cataract compli-cated with macular edema
Objective To observe the clinical effect of phacoemulsification combined with intravitreal anti-vascular endothelial growth factor(anti-VEGF)injection in treating cataract combined with various macular edema.Meth-ods A retrospective case-control study.20 cases of ophthalmic inpatient cataract combined with various macular diseases(diabetic macular edema,senile macular degeneration,high myopia CNV)from January 2019 to December 2022 were col-lected and were randomly divided into two groups.The A group(10 patients)received phacoemulsification combined with intraocular lens implantation,intraoperative intravitreal anti-VEGF drug injection.The B group(10 patients)underwent phacoemulsification combined with intraocular lens implantation.The follow-up period was 1-month,the differences in an-terior chamber and vitreous condition,best corrected visual acuity(BCVA),macular foveal thickness(CMT),and intra-ocular pressure between the two groups were observed.Results The postoperative CMT and intraocular pressure(IOP)compared with preoperative were decreased in A group,and were significantly different from B group(P<0.05).The BCVA improved in bothgroups compared with preoperative,and A group was significantly better than B group(P<0.05).Conclusions Cataract ultrasound combined with vitreous anti-VEGF drugs is safe and effective in the treatment of cata-ract and macular edema,and is worth popularizing.

PhacoemulsificationVitreous injectionAnti-VEGFcataract macular edema

张静、张大传、查明轩、程红

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230000 合肥市第三人民医院眼科

超声乳化吸除术 玻璃体腔注射 抗血管内皮生长因子 白内障黄斑水肿

2024

临床眼科杂志
安徽医科大学,安徽眼科研究所

临床眼科杂志

CSTPCD
影响因子:0.791
ISSN:1006-8422
年,卷(期):2024.32(3)