纳米技术在眼部疾病中的应用
Application of Nanotechnology in Eye Diseases
李君一 1刘科琳 1袁福杰 1王英2
作者信息
- 1. 471002 洛阳市第三人民医院
- 2. 130000 吉林大学第二医院
- 折叠
摘要
由于眼的独特解剖及生理屏障作用,有效的眼部药物递送存在巨大的挑战,目前传统的非侵入性及侵入性治疗存在生物利用度低、部分伴随着严重的不良反应.纳米眼科学中的纳米技术处于临床应用的早期阶段,纳米级材料在给定的每单位尺寸下,将提供更多的合成反应场所,纳米技术有可能通过克服眼部生理解剖屏障改善药物生物利用度及外科手术干预的失败率,增强现有的诊断筛查工具.本综述重点介绍了纳米技术在眼部疾病诊断及治疗的相关尝试及进展,本文所述的进展可能为新的、高效的眼科纳米药物铺平道路.
Abstract
Due to the unique anatomy and physiological barrier function of the eye,there are huge challenges in effective ocular drug delivery.The current traditional non-invasive and invasive treatments have low bioavailability and some are accompanied by serious adverse reactions.Nanotechnology in nano-ophthalmology is in the early stages of clinical application.Nanoscale materials will provide more sites for synthetic reactions at a given size per unit.Nanotechnology has the potential to improve drug bioavailability by overcoming ocular physiological anatomical barriers.The degree and failure rate of surgical interventions,and enhancing existing diagnostic screening tools.This review focuses on the related at-tempts and progress of nanotechnology in the diagnosis and treatment of ocular diseases.The progress described in this ar-ticle may pave the way for new and highly effective ophthalmic nanomedicines.
关键词
纳米粒子/脂质体/树枝状大分子/金纳米粒子Key words
Nanoparticles/Liposomes/Dendrimers/Gold nanoparticles引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据