The effect of intravitreous injection of compaCI:llin in the treatment of diabetes mellitus macular edema
Objective To evaluate and analyze the influence factors and short-term curative effect of intravitreal injection of Compaplexipes in diabetic macular edema(DME).Methods Prospective study.94 eyes of 94 patients with DME who received intravitreal injection of Compaercep in our hospital were collected as the study objects,and the time was set to be from October 2022 to October 2023.General information such as age,gender,body mass index(BMI),dia-betes course,macular edema course,macular edema classification,and injection frequency were collected.Glycated he-moglobin(HbA1c),total cholesterol,serum creatinine level,low density lipoprotein,triglyceride,blood urea nitrogen,blood glucose and other biochemical indicators;Baseline vision,baseline CRT and other imaging indicators.Short-term ef-ficacy after intravitreal injection of Compaercept was compared and analyzed.Visual acuity improvement value was defined as the qualified group with BCVA improving visual acuity for 2 or more lines,and the non-qualified group with BCVA was defined as the non-qualified group.Univariate analysis and binary Logistic regression were used to analyze the factors af-fecting the short-term efficacy of DME patients after treatment,expressed as odds ratio(OR)and 95%confidence interval(CI).According to the morphological characteristics of edema,the patients were divided into diffuse group(32 cases,32 eyes),cystic group(31 cases,31 eyes)and subretinal fluid group(31 cases,31 eyes).Results Univariate analysis showed that age,BMI,duration of diabetes,duration of macular edema,type of macular edema,serum creatinine level,HbA1c,baseline visual acuity and improved visual acuity after treatment were statistically significant(all P<0.05).There was no statistical significance in total cholesterol,baseline CRT,low density lipoprotein,triglyceride,blood urea nitrogen,blood glucose,gender,and injection times(all P>0.05).Binary Logistic regression analysis results can be ob-tained:Age(OR=0.903,95%CI:0.827-0.987),serum creatinine level(OR=0.955,95%CI:0.913-0.999),HbA1c(OR=0.438,95%CI:0.201-0.954),type of cystoid edema(OR=0.013,95%CI:0.008-0.564)and subretinal fluid type(OR=0.005,95%CI:0.058-0.421)were independent risk factors for visual acuity failure after treatment(all P<0.05).Baseline visual acuity(OR=12.423,95%CI:1.956-18.054)was a protective factor for visual acuity attainment after treatment(P<0.05).Total cholesterol,baseline CRT,low density lipoprotein,triglyceride,blood urea nitrogen,blood glucose and other indicators had no statistical significance on the improvement of visual acuity after treatment(all P>0.05).Compared with before treatment,the best corrected visual acuity of the three groups of patients after intravitreal injection of Compaer-cept decreased(all P<0.05).Compared with saccoid group and subretinal fluid group,the best corrected visual acuity in diffuse group decreased faster at 1 month,3 months and 6 months after treatment,and the differences were statistically sig-nificant(all P<0.05).There was no significant difference in the best corrected visual acuity between the cystoid group and the subretinal fluid group at 1,3 and 6 months after treatment(P>0.05).Compared with before treatment,CRT in all three groups after intravitreal injection of Compaplomb decreased(all P<0.05).CRT in diffuse group decreased faster at 1 month,3 months and 6 months after treatment compared with saccoid group and subretinal fluid group,and the differ-ences were statistically significant(all P<0.05).There was no significant difference in CRT between cystoid group and subretinal fluid group 1 month after treatment(P>0.05),while there was significant difference in CRT between cystoid group and subretinal fluid group 3 months and 6 months after treatment(all P<0.05).Conclusions Age,HbA1c,serum creatinine level,cystic type and subretinal fluid type of macular edema were independent risk factors for the efficacy of in-travitreal injection of Compaplcept for DME,and increased baseline visual acuity was independent protective factor for the efficacy of intravitreal injection of Compaplcept for DME.Intravitreal injection of Compaercept was effective in the treat-ment of DME patients with different morphological characteristics,the diffuse group had the best therapeutic effect,and there was no significant difference between the saccoid group and the subretinal fluid group.
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