Observation of SD-OCT biomarkers after anti-inflammatory and anti-VEGF treatment for macular edema secondary to retinal vein occlusion
Objective To evaluate the changes in visual function and spectral domain optical coherence tomogra-phy(SD-OCT)biomarkers in patients with retinal vein obstruction secondary macular edema(RVO-ME)after anti-inflammatory and anti-vascular endothelial growth factor(VEGF)treatment,and to provide evidence for clinical selection of appropriate treatment.Methods For prospective study,106 patients(106 eyes)diagnosed with RVO-ME in the Affili-ated Hospital of Heze Medical College from June 2019 to November 2021 were randomly divided into two groups:A and B.Group A was given intravitreal injection of Ranibizumab,group B was given intravitreal injection of dexamethasone.Bio-markers of best corrected visual acuity(BCVA)and SD-OCT and adverse reactions were recorded at baseline and 12mo af-ter the first treatment,and changes in BCVA and SD-OCT and incidence of adverse reactions were compared between the two groups before and after treatment.Results BCVA and SD-OCT biomarkers were significantly improved in both groups after treatment(P<0.01).Serous retinal detachment(SRD)degradation in group B was significantly better than that in group A at 12mo,and the number of hyperreflective retinal foci(HRFs)in group B was significantly less than that in group A after the treatment.Compared with the two groups,there was no statistical significance in the changes of external retinal membrane(ELM),ellipsoid zone(EZ)and thedisorganization of retinal innerlayers(DRIL)(P>0.05).There was no significant difference in the incidence of subconjunctival hemorrhage and lens opacity between the two groups after treatment,but 10 patients in group B showed increased intraocular pressure(IOP),which was significantly higher than that in group A.Conclusions Both anti-inflammatory and anti-VEGF treatment were effective for RVO-ME,BCVA and SD-OCT biomarkers were improved,anti-inflammatory treatment was superior to anti-VEGF treatment in improving SRD,and there was no difference between anti-inflammatory and anti-VEGF treatment in the number of HRFs.
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