Discussion the mechanism of Shaoyao Gancao decoction in the treatment of chronic atrophic gastritis based on network pharmacology
Objective To explore the mechanism of Shaoyao Gancao decoction in the treatment of chronic atrophic gastritis(CAG)by network pharmacology.Methods The traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP)database and literature mining were used to sort out the chemical constituents of Shaoyao Gancao decoction.GeneCards,OMIM,DrugBank and TTD databases were used to collect relevant targets of CAG.The Venn diagram was used to screen the intersection targets,and the"active component-disease target"network was constructed by Cytoscape software.The protein-protein interaction(PPI)network was constructed by String database and Cytoscape software.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed by Metascape database.Molecular docking was performed by AutoDock software.Results A total of 103 effective active ingredients of Shaoyao Gancao decoction and 76 CAG-related targets were screened.The important active ingredients include quercetin,kaempferol,naringenin and licochalcone A.The core targets include akt serine/threonine kinase 1(AKT1),tumor protein p53(TP53),tumor necrosis factor(TNF),etc.The KEGG pathway is mainly enriched in interleukin-17(IL-17),TNF,hypoxia-inducible factor-1(HIF-1)and other pathways.Molecular docking results showed that the compounds had good binding ability with key targets.Conclusion Shaoyao Gancao decoction can play a therapeutic role in CAG through multi-component,multi-target and multi-pathway.
NETL
NSTL
万方数据
维普
