Effects of sodium hyaluronate combined with arthroscopic minimally invasive surgery on knee joint function and inflammatory factors levels in elderly patients with knee osteoarthritis
Objective To investigate the effects of sodium hyaluronate combined with arthroscopic minimally invasive surgery on knee joint function and inflammatory factors levels in elderly patients with knee osteoarthritis(KOA).Methods A total of 158 elderly KOA patients admitted in our hospital from January 2019 to January 2021 were selected as the research objects and divided into control group and observation group by random number table method,with 79 cases in each group.The control group was treated with arthroscopic minimally invasive surgery,and the observation group was treated with sodium hyaluronate on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.20%,which was significantly higher than 84.81%in the control group(P<0.05).After 1,3 and 6 months of treatment,the Lysholm score of knee joint in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-8(IL-8),interleukin-17(IL-17)and cyclooxygenase-2(COX-2)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of total N-terminal propeptide of type Ⅰ procollagen(TPⅠNP),osteocalcin(BGP)and osteoprotegerin(OPG)in the observation group were higher than those in the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Sodium hyaluronate combined with arthroscopic minimally invasive surgery in the treatment of elderly patients with KOA has a significant effect,which can improve knee joint function and bone metabolism,reduce the levels of inflammatory factors and the incidence of complications.
NETL
NSTL
万方数据
维普
