Effect of hydroxychloroquine combined with low molecular weight heparin sodium and low-dose aspirin in the treatment of antiphospholipid antibody related recurrent spontaneous abortion and its influences on coagulation function and immune balance
Objective To investigate the effect of hydroxychloroquine combined with low molecular weight heparin sodium and low-dose aspirin in the treatment of antiphospholipid antibody related recurrent spontaneous abortion(RSA)and its influences on coagulation function and immune balance.Methods A total of 106 patients with antiphospholipid antibody related RSA admitted from May 2022 to May 2023 were selected as the study objects and randomly divided into control group and observation group,with 58 cases in each group.The control group was treated with low molecular weight heparin sodium and low-dose aspirin,and the observation group was treated with hydroxychloroquine on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the prothrombin time(PT)and activited partial thomboplastin time(APTT)in the observation group were longer than those in the control group,while the D-dimer(D-D)and fibrinogen(FIB)levels were lower than those in the control group(P<0.05).After treatment,the levels of interleukin-2(IL-2)and interleukin-1(IL-1)in the observation group were lower than those in the control group,while the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Hydroxychloroquine combined with low molecular weight heparin sodium and low-dose aspirin in the treatment of antiphospholipid antibody related RSA has a significant effect,it can regulate coagulation function and immune balance of patients,and reduce the incidence of adverse reactions,which is worth promoting.
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NSTL
万方数据
维普
