Effect of enoxaparin sodium combined with phloroglucinol in the treatment of patients with threatened abortion and its influences on E2,P and β-HCG levels
Objective To analyze the clinical effect of enoxaparin sodium combined with phloroglucinol in the treatment of patients with threatened abortion.Methods A total of 76 patients with threatened abortion diagnosed and treated in our hospital from March 2020 to February 2023 were selected as the research objects.According to the parity of admission time sequence number,the patients were divided into control group(odd number)and observation group(even number),with 38 cases in each group.The control group was treated with intramuscular injection of phloroglucinol injection,and the observation group was treated with subcutaneous injection of enoxaparin sodium injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results The abdominal pain relief time,vaginal hemostasis time and lumbar acid relief time in the observation group were shorter than those in the control group(P<0.05).At 5 d after treatment,the levels of estradiol(E2),progesterone(P)and β-human chorionic gonadotropin(β-HCG)in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05).At 5 d after treatment,the activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT)and tissue plasminogen activator(T-PA)level in the observation group were higher than those in the control group,and plasminogen activator inhibitor-1(PAI-1)level was lower than that in the control group(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P<0.05).Conclusion Enoxaparin sodium combined with phloroglucinol can promote the regression of clinical symptoms in patients with threatened abortion,regulate endocrine indexes,improve coagulation function,and reduce the risk of threatened abortion and other complications to a certain extent,it is helpful to improve the pregnancy safety of patients and has important application value.
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