Predictive value of vascular resistance index combined with UL16 binding protein 2 on the sensitivity of rectal cancer to neoadjuvant chemoradiotherapy
Objective To analyze the predictive value of vascular resistance index(RI)combined with UL16 binding protein 2(ULBP2)on the sensitivity of rectal cancer to neoadjuvant chemoradiotherapy(NCRT).Methods A total of 84 patients with rectal cancer admitted from January 2018 to April 2022 were included.All patients were treated with NCRT.The patients who were effective in NCRT treatment were included in the effective group,and those who were ineffective were included in the ineffective group.The general data,endorectal ultrasonography(ERUS)and serological indicators were compared between the two groups.Binary Logistic regression model was used to analyze the related factors affecting the sensitivity of NCRT treatment in patients with rectal cancer.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of RI,ULBP2 and their combination on the sensitivity of NCRT treatment in patients with rectal cancer.Results The total effective rate of 84 patients with rectal cancer treated by NCRT was 41.67%(35/84).35 patients with effective treatment were included in the effective group,and 49 patients with ineffective treatment were included in the ineffective group.Binary Logistic regression analysis showed that mucinous adenocarcinoma,RI and ULBP2 were significantly correlated with the sensitivity of NCRT in patients with rectal cancer(P<0.05).RI combined with ULBP2 has a higher predictive value for the sensitivity of NCRT in patients with rectal cancer.Conclusion RI and ULPB2 in ERUS indicators are significantly correlated with the efficacy of NCRT for rectal cancer,and the combination of the two has a higher predictive value for NCRT sensitivity in patients with rectal cancer,which is worthy of application and promotion.
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