血管阻力指数联合UL16结合蛋白2对直肠癌新辅助放化疗敏感性的预测价值
Predictive value of vascular resistance index combined with UL16 binding protein 2 on the sensitivity of rectal cancer to neoadjuvant chemoradiotherapy
李海珍 1周亚翠 1屈婉红 2李志丹1
作者信息
- 1. 宝鸡市凤翔区医院,陕西 宝鸡,721400
- 2. 宝鸡市中心医院,陕西 宝鸡,721000
- 折叠
摘要
目的 分析血管阻力指数(RI)联合UL16 结合蛋白 2(ULBP2)对直肠癌新辅助放化疗(NCRT)治疗敏感性的预测价值.方法 纳入 2018 年 1 月至 2022 年 4 月收治的 84 例直肠癌患者,所有患者均行NCRT治疗.将NCRT治疗有效者纳入有效组,无效者纳入无效组.比较两组的一般资料、直肠腔内超声(ERUS)以及血清学指标.使用二元Logistic回归模型分析影响直肠癌患者NCRT治疗敏感性的相关因素,使用受试者工作特征(ROC)曲线分析RI、ULBP2 以及二者联合对直肠癌患者NCRT治疗敏感性的预测价值.结果 84 例直肠癌患者经NCRT治疗,治疗总有效率为 41.67%(35/84).将治疗有效者35 例纳入有效组,无效者 49 例纳入无效组.二元Logistic回归分析结果显示,黏液腺癌、RI、ULBP2均与直肠癌患者NCRT治疗敏感性明显相关(P＜0.05).RI联合ULBP2对直肠癌患者NCRT治疗敏感性的预测价值更高.结论 ERUS指标中RI和ULPB2均与直肠癌NCRT疗效明显相关,其中二者联合对直肠癌患者NCRT敏感性的预测价值更高,值得应用及推广.
Abstract
Objective To analyze the predictive value of vascular resistance index(RI)combined with UL16 binding protein 2(ULBP2)on the sensitivity of rectal cancer to neoadjuvant chemoradiotherapy(NCRT).Methods A total of 84 patients with rectal cancer admitted from January 2018 to April 2022 were included.All patients were treated with NCRT.The patients who were effective in NCRT treatment were included in the effective group,and those who were ineffective were included in the ineffective group.The general data,endorectal ultrasonography(ERUS)and serological indicators were compared between the two groups.Binary Logistic regression model was used to analyze the related factors affecting the sensitivity of NCRT treatment in patients with rectal cancer.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of RI,ULBP2 and their combination on the sensitivity of NCRT treatment in patients with rectal cancer.Results The total effective rate of 84 patients with rectal cancer treated by NCRT was 41.67%(35/84).35 patients with effective treatment were included in the effective group,and 49 patients with ineffective treatment were included in the ineffective group.Binary Logistic regression analysis showed that mucinous adenocarcinoma,RI and ULBP2 were significantly correlated with the sensitivity of NCRT in patients with rectal cancer(P<0.05).RI combined with ULBP2 has a higher predictive value for the sensitivity of NCRT in patients with rectal cancer.Conclusion RI and ULPB2 in ERUS indicators are significantly correlated with the efficacy of NCRT for rectal cancer,and the combination of the two has a higher predictive value for NCRT sensitivity in patients with rectal cancer,which is worthy of application and promotion.
关键词
直肠腔内超声/血管阻力指数/UL16结合蛋白2/直肠癌/新辅助放化疗/敏感性Key words
endorectal ultrasonography/vascular resistance index/UL16 binding protein/rectal cancer/neoadjuvant chemoradiotherapy/sensitivity引用本文复制引用
基金项目
宝鸡市卫生健康委科研立项项目(2019)(2019-77)
出版年
2024
NETL
NSTL
万方数据