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血脂指标对突发感音神经性聋发病的影响

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目的 探究血脂指标对突发感音神经性聋(SSNHL)发病的影响,为SSNHL辅助诊断指标的选择提供参考依据.方法 选取 2017 年 1 月至 2022 年 12 月在南通市通州区人民医院耳鼻喉科住院治疗的 198 例SSNHL患者作为SSNHL组,另选取同期在我院住院治疗、一般资料与SSNHL组匹配且没有耳部疾病的198例患者作为对照组.收集并比较两组患者的性别、年龄、体质指数、合并慢性疾病种类以及血脂指标,分析SSNHL发病的影响因素.结果 单因素分析结果显示,两组的性别、年龄、体质指数、合并糖尿病、高血压、冠心病占比、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AⅠ(apo AⅠ)、载脂蛋白B(apo B)水平比较,差异不显著(P>0.05);两组的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及脂蛋白(a)[LP(a)]水平比较,差异具有统计学意义(P<0.05).多因素Logistic回归分析结果显示,TC、LDL-C是SSNHL发病的独立影响因素(P<0.05).结论 TC、LDL-C是SSNHL发病的独立影响因素,其可能在SSNHL发病中起重要作用,因此临床诊断SSNHL时应当重点关注TC、LDL-C水平变化,以此作为辅助诊断的常规检测指标.
Effect of blood lipid index on the incidence of sudden sensorineural hearing loss
Objective To explore the effect of blood lipid index on the incidence of sudden sensorineural hearing loss(SSNHL),and to provide reference for the selection of auxiliary diagnostic indicators for SSNHL.Methods A total of 198 patients with SSNHL who were hospitalized in the otolaryngology department of Nantong Tongzhou People's Hospital from January 2017 to December 2022 were selected as the SSNHL group.In addition,198 patients who were hospitalized in our hospital during the same period,whose general data were matched with the SSNHL group and had no ear disease were selected as the control group.The gender,age,body mass index,types of chronic diseases and blood lipid of the two groups were collected and compared,and the influencing factors for the incidence of SSNHL were analyzed.Results The results of univariate analysis showed that there were no significant differences in gender,age,body mass index,proportion of diabetes mellitus,hypertension,coronary heart disease,triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),apolipoprotein AⅠ(apo AⅠ)and apolipoprotein B(apo B)levels between the two groups(P>0.05);there were statistically significant differences in the levels of total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C)and lipoprotein(a)[LP(a)]between the two groups(P<0.05).Multivariate Logistic regression analysis showed that TC and LDL-C were independent influencing factors for the incidence of SSNHL(P<0.05).Conclusion TC and LDL-C are independent influencing factors for the incidence of SSNHL,which may play an important role in the pathogenesis of SSNHL.Therefore,the clinical diagnosis of SSNHL should focus on the levels of TC and LDL-C as routine indicators for auxiliary diagnosis.

sudden sensorineural hearing losstotal cholesterollow density lipoprotein-cholesterolblood lipid index

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南通市通州区人民医院耳鼻喉科,江苏 南通,226300

突发感音神经性聋 总胆固醇 低密度脂蛋白胆固醇 血脂指标

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(2)
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