Application effect of intravitreal injection of anti-vascular endothelial growth factor in laser photocoagulation for diabetic retinopathy
Objective To investigate the application effect of intravitreal injection of anti-vascular endothelial growth factor(VEGF)in laser photocoagulation for diabetic retinopathy.Methods A total of 120 patients with diabetic retinopathy admitted from June 2021 to June 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 60 cases in each group.The two groups were treated with laser photocoagulation,and the observation group was given intravitreal injection of conbercept at 3-5 d before surgery.The therapeutic effects of the two groups were compared.Results After treatment,the best corrected visual acuity(BCVA)of the two groups increased,and that of the observation group was higher than the control group(P<0.05).After treatment,the level of placental growth factor(PIGF)in the two groups decreased,the level of pigment epithelium derived factor(PEDF)increased,and those in the observation group were better than the control group(P<0.05).The total incidence of complications in the observation group was 8.33%,which was significantly lower than 30.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Intravitreal injection of anti-VEGF has a significant adjuvant therapeutic effect in laser photocoagulation for diabetic retinopathy,which can reduce the damage of epiretinal membrane tissue,improve the level of cytokines and reduce the incidence of complications.
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