沙库巴曲缬沙坦治疗维持性血液透析合并慢性心力衰竭患者的临床效果
Clinical effect of sacubitril/valsartan in the treatment of maintenance hemodialysis patients with chronic heart failure
姚转娥 1王鹏波 1付秦娟 1宋琼 1刘爱 1张鹏2
作者信息
- 1. 陕西省第二人民医院,陕西 西安,710005
- 2. 西京医院,陕西 西安,710000
- 折叠
摘要
目的 探讨沙库巴曲缬沙坦治疗维持性血液透析合并慢性心力衰竭患者的有效性和安全性.方法 选取在陕西省第二人民医院血液净化中心行维持性血液透析且合并慢性心力衰竭的 21 例患者为研究对象,均给予沙库巴曲缬沙坦治疗12周.比较治疗前、后的生命体征、生化指标、心功能指标、生活质量及不良反应发生情况.结果 治疗后,维持性血液透析合并慢性心力衰竭患者的收缩压、舒张压、纽约心脏病学会(NYHA)分级Ⅲ级占比、N末端B型脑钠肽前体(NT-proBNP)水平低于治疗前,左室射血分数(LVEF)高于治疗前,左室舒张末期内径(LVDD)、左室收缩末期内径(LVDS)小于治疗前(P＜0.05).治疗后,维持性血液透析合并慢性心力衰竭患者的躯体健康、精神健康评分高于治疗前(P<0.001).结论 沙库巴曲缬沙坦有利于改善维持性血液透析合并慢性心力衰竭患者的心功能及生活质量.
Abstract
Objective To investigate the efficacy and safety of sacubitril/valsartan in the treatment of maintenance hemodialysis patients with chronic heart failure.Methods Twenty-one patients with maintenance hemodialysis complicated with chronic heart failure in the blood purification center of Shaanxi Provincial Second People's Hospital were selected as the study objects.All patients were treated with sacubitril/valsartan for 12 weeks.The vital signs,biochemical indexes,cardiac function indexes,quality of life and adverse reactions before and after treatment were compared.Results After treatment,the systolic blood pressure,diastolic blood pressure,proportion of New York Heart Association(NYHA)gradeⅢ,and N-terminal pro-brain natriuretic peptide(NT-proBNP)level in patients with maintenance hemodialysis complicated with chronic heart failure were lower than those before treatment,left ventricular ejection fraction(LVEF)was higher than that before treatment,while left ventricular end-diastolic diameter(LVDD)and left ventricular end-systolic dimension(LVDS)were less than those before treatment(P<0.05).After treatment,the scores of physical health and mental health in patients with maintenance hemodialysis complicated with chronic heart failure were higher than those before treatment(P<0.001).Conclusion Sacubitril/valsartan is beneficial to improve cardiac function and quality of life in patients with maintenance hemodialysis complicated with chronic heart failure.
关键词
血液透析/慢性心力衰竭/沙库巴曲缬沙坦/心功能/生活质量Key words
hemodialysis/chronic heart failure/sacubitril/valsartan/cardiac function/quality of life引用本文复制引用
基金项目
陕西省卫生健康科研项目(2022E013)
出版年
2024
NETL
NSTL
万方数据