Effects of rosuvastatin calcium combined with hydroclopidogrel on the outcome and inflammatory indexes of interventional therapy in patients with coronary heart disease
Objective To analyze the effects of rosuvastatin calcium combined with hydroclopidogrel on the outcome and inflammatory indexes of interventional therapy in patients with coronary heart disease.Methods A total of 80 patients with coronary heart disease treated by interventional therapy in our hospital from January 2020 to December 2022 were selected as the research objects.According to the difference of treatment plan,the patients were divided into single drug group(40 cases,hydroclopidogrel treatment)and combined group(40 cases,rosuvastatin calcium combined with hydroclopidogrel treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was significantly higher than that in the single drug group(P<0.05).After treatment,the levels of C-reactive protein(CRP),procalcitonin(PCT)and soluble CD40 ligand(sCD40L)in the combined group were significantly lower than those in the single drug group,and the level of insulin-like growth factor-1(IGF-1)was significantly higher than that in the single drug group(P<0.05).After treatment,the QT dispersion,QRS wave duration,ventricular premature contraction and short ventricular tachycardia in the combined group were significantly lower than those in the single drug group,and the standard deviation of sinus rhythm R-R interval and the average value of adjacent sinus rhythm R-R interval were significantly higher than those in the single drug group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The incidence of cardiovascular and cerebrovascular adverse events in the combined group was lower than that in the single drug group(P<0.05).Conclusion Rosuvastatin calcium combined with hydroclopidogrel can improve the outcome of interventional therapy in patients with coronary heart disease and quickly eliminate the inflammatory stress response.
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