首页|度拉糖肽治疗非酒精性脂肪性肝病合并2型糖尿病患者的效果及对血清指标的影响

度拉糖肽治疗非酒精性脂肪性肝病合并2型糖尿病患者的效果及对血清指标的影响

扫码查看
目的 探讨度拉糖肽治疗非酒精性脂肪性肝病合并2型糖尿病患者的效果及对血清指标的影响.方法 选取2020年 2月至 2021 年 2 月收治的 90 例非酒精性脂肪性肝病合并 2 型糖尿病患者为研究对象,根据不同治疗方法将其分为对照组和观察组,各45例.两组均行常规治疗,对照组在常规治疗基础上口服盐酸吡格列酮片治疗,观察组在常规治疗基础上皮下注射度拉糖肽注射液治疗.比较两组的治疗效果.结果 观察组的治疗总有效率高于对照组(P<0.05).治疗后,观察组的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、肝硬度值(LSM)、脂肪受控衰减参数(CAP)、层黏连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)水平低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组(P<0.05).两组的不良反应总发生率无显著差异(P>0.05).结论 度拉糖肽治疗非酒精性脂肪性肝病合并2 型糖尿病患者的效果显著.
Effect of dulaglutide in the treatment of patients with nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus and its influence on serum indexes
Objective To investigate the effect of dulaglutide in the treatment of patients with nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus and its influence on serum indexes.Methods A total of 90 patients with nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus admitted from February 2020 to February 2021 were selected as the research objects.According to different treatment methods,the patients were divided into control group and observation group,with 45 cases in each group.Both groups received routine treatment,the control group was treated with oral pioglitazone hydrochloride tablets on the basis of routine treatment,and the observation group was treated with subcutaneous injection of dulaglutide injection on the basis of routine treatment.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),homeostasis model insulin resistance index(HOMA-IR),triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),alanine aminotransferase(ALT),liver stiffness measurement(LSM),fat controlled attenuation parameter(CAP),laminin(LN),hyaluronic acid(HA),typeⅢprocollagen(PC-Ⅲ)and typeⅣcollagen(Ⅳ-C)levels in the observation group were lower than those in the control group,the level of high density lipoprotein-cholesterol(HDL-C)was higher than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Dulaglutide has significant effect in the treatment of patients with nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus.

dulaglutidenonalcoholic fatty liver diseasetype 2 diabetes mellitus

刘宏敏、张颖、肖婉侠、王蓓

展开 >

通用环球西安西航医院消化内分泌肾病内科,陕西 西安,710000

空军军医大学第一附属医院内分泌代谢科,陕西 西安,710032

扶风县人民医院内分泌风湿病科,陕西 宝鸡,722200

度拉糖肽 非酒精性脂肪性肝病 2型糖尿病

2024

临床医学研究与实践

临床医学研究与实践

ISSN:
年,卷(期):2024.9(2)
  • 14