Effects of dexmedetomidine combined with ropivacaine for paravertebral nerve block on analgesic effect and cognitive function in patients undergoing radical resection of lung cancer
Objective To investigate the effects of dexmedetomidine combined with ropivacaine for paravertebral nerve block on analgesic effect and cognitive function in patients undergoing radical resection of lung cancer.Methods A total of 90 patients who underwent radical resection of lung cancer from May 2019 to May 2022 were selected and randomly divided into control group and observation group,with 45 cases in each group.The control group was adopted ropivacaine for paravertebral nerve block,and the observation group was adopted dexmedetomidine combined with ropivacaine for paravertebral nerve block.The anesthetic effects of the two groups were compared.Results At 6,12,24 and 48 h after operation,the Visual Analogue Score(VAS)score of the observation group was lower than that of the control group(P<0.05).After intubation,at the beginning of operation,at the end of operation and 2 h after operation,the levels of cortisol(Cor)and norepinephrine(NE)in the observation group were lower than those in the control group(P<0.05).At 48 h after operation,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the control group(P<0.05).At 1 d after operation,the scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)in the observation group were higher than those in the control group(P<0.05).Conclusion Compared with ropivacaine alone,dexmedetomidine combined with ropivacaine for paravertebral nerve block not only has better analgesic effect,but also reduces stress response and inflammatory factor levels and promotes the recovery of cognitive function of patients,which is worthy of promotion.
dexmedetomidineropivacaineparavertebral nerve blockradical resection of lung canceranalgesic effectcognitive function
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