Objective To explore the clinical value of Yinchen Jiedu decoction in the treatment of acne patients.Methods A total of 150 acne patients treated from September 2018 to September 2021 were selected as the study objects and divided into control group and experimental group according to random envelope method,with 75 cases in each group.The control group was treated with isotretinoin soft capsules,and the experimental group was treated with Yinchen Jiedu decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the lesion type,number and color scores of the two groups decreased,those of the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-1(IL-1),soluble interleukin-2 receptor(sIL-2R)and interleukin-8(IL-8)in both groups decreased,those of the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Y inc he n Jie du decoction in the treatment of acne has a remarkable effect,it can reduce the level of cytokines in skin lesions and promote the improvement of skin lesions,with good safety,which is worthy of promotion.