Objective To analyze the influence of Suanzaoren decoction and dexzopiclone tablets on sleep quality of patients with long term insomnia.Methods A total of 120 patients with long term insomnia admitted from May 2019 to November 2021 were selected as the study objects and divided into conventional group(60 cases,treated with dexzopiclone tablets)and observation group(60 cases,treated with Suanzaoren decoction and dexzopiclone tablets)by random number method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P<0.05).After treatment,the levels of dopamine(DA),brain derived neurotrophic factor(BDNF),neurotrophin-3(NT-3),nerve growth factor(NGF)and 5-hydroxytryptamine(5-HT)in the observation group were significantly higher than those in the conventional group(P<0.05).After treatment,the vertebral artery diastolic flow velocity(Vd),systolic blood flow velocity(Vs)and mean flow velocity(MFV)in the observation group were significantly greater than those in the conventional group(P<0.05).After treatment,Pittsburgh Sleep Quality Index(PSQI),Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)scores in the observation group were significantly lower than those in the conventional group,and World Health Organization Quality of Life Scale-100(WHOQOL-100)score was significantly higher than that in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Suanzaoren decoction and dexzopiclone tablets in the treatment of long term insomnia has a remarkable effect,it can effectively regulate the levels of neurotransmitters and vertebral artery blood flow in patients,ameliorate sleep disorders and negative emotions,and promoto the quality of life,which is worth promoting.
long term insomniaSuanzaoren decoctiondexzopiclone tabletssleep quality
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