炎性标志物与卒中后抑郁的研究进展
Research progress of inflammatory markers and post-stroke depression
肖艾妮 1王翔宇 1刘聪杰 1高文瑞 1曹洋1
作者信息
- 1. 三峡大学第三临床医学院/国药葛洲坝中心医院神经内科,湖北 宜昌,443002
- 折叠
摘要
卒中后抑郁(PSD)是一种生物心理社会疾病,会影响在任何时间点发生卒中的个体.缺血性脑卒中(IS)中幸存者PSD的患病率为20%～60%.PSD预后较差,若早期不加以干预或治疗,严重者可导致残疾.免疫反应和炎症反应在IS的发生、发展中起着重要作用,IS引起的炎性标志物升高可能在抑郁症状的发病机制中起重要作用.近年来国内外较多学者对神经炎症与PSD的关系研究较多,现就神经炎症在PSD中的研究进展作一综述,旨在为PSD的综合诊疗提供更全面的参考.
Abstract
Post-stroke depression(PSD)is a bio-psycho-social disease that affects individuals who have stroke at any point in time.The prevalence of PSD in survivors of ischemic stroke(IS)is 20%-60%.The prognosis of PSD is poor,and if not intervened or treated early,severe cases can lead to disability.Immune and inflammatory responses play important roles in the occurrence and development of IS,and the elevation of inflammatory markers caused by IS may play an important role in the pathogenesis of depressive symptoms.In recent years,many scholars at home and abroad have studied the relationship between neuroinflammation and PSD.This article reviews the research progress of neuroinflammation in PSD,aiming to provide a more comprehensive reference for the comprehensive diagnosis and treatment of PSD.
关键词
卒中后抑郁/缺血性脑卒中/中性粒细胞/淋巴细胞/系统免疫炎症指数Key words
post-stroke depression/ischemic stroke/neutrophils/lymphocyte/systemic immune-inflammation index引用本文复制引用
出版年
2024
NETL
NSTL
万方数据