Study on the cardioprotective effect and mechanism of Shenyu Yangxin decoction on rats with pressure load chronic heart failure
Objective To explore the effect and mechanism of Shenyu Yangxin decoction on the cardiac function of rats with pressure load chronic heart failure(CHF).Methods Thirty SD male rats were randomly divided into blank group,model group and Chinese medicine group(10 rats in each group),in which the blank group only received abdominal aortic threading without coarctation,and both the model group and the Chinese medicine group received abdominal aortic coarctation.During the operation,1 rat died in the blank group and the Chinese medicine group and 2 rats died in the model group.After 12 weeks of successful modeling,the Chinese medicine group was fed Shenyu Yangxin decoction(granules)at 13.2 g/(kg·d),and the blank group and the model group were fed the same dose of normal saline.The electrocardiogram,hemodynamics and serum indexes of the three groups were compared after 30 d of continuous feeding.Results The amplitude of P wave in the Chinese medicine group was less than that in the model group,the duration of P wave and QRS were shorter than those in the model group,and the ST height was greater than that in the model group(P<0.05).The left ventricular end-diastolic pressure(LVEDP)in the Chinese medicine group was significantly lower than that in the model group,the left ventricular systolic pressure(LVSP)and maximal rate of rise in blood pressure in the ventricular chamber(+dp/dtmax)were significantly higher than those in the model group(P<0.05).The levels of endothelin-1(ET-1)and malondialdehyde(MDA)in the Chinese medicine group were significantly lower than those in the model group,and the level of superoxide dismutase(SOD)was significantly higher than that in the model group(P<0.05).Conclusion Shenyu Yangxin decoction can effectively improve the cardiac function of pressure load CHF rats,which may be related to improving hemodynamics,microvascular endothelial function and oxidative stress.
chronic heart failurepressure loadShenyu Yangxin decoctioncardiac function
NETL
NSTL
万方数据
维普
