Effect of reduced glutathione combined with methimazole in the treatment of hyperthyroidism and its influences on oxidative stress indexes,ICAM-1 and IGF-1 levels
Objective To investigate the effect of reduced glutathione combined with methimazole in the treatment of hyperthyroidism and its influences on oxidative stress indexes,intercellular cell adhesion molecule-1(ICAM-1)and insulin like growth factor-1(IGF-1)levels.Methods A total of 100 patients with hyperthyroidism admitted in our hospital from June 2021 to June 2022 were selected as the research objects.According to the difference of treatment methods,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with methimazole,and the observation group was treated with reduced glutathione combined with methimazole.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of free triiodothyronine(FT3)and free thyroxine(FT4)in the observation group were lower than those in the control group,and the level of thyroid stimulating hormone(TSH)was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,and the levels of superoxide dismutase(SOD)and myeloperoxidase(MPO)were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of ICAM-1 and IGF-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Reduced glutathione combined with methimazole in the treatment of hyperthyroidism can improve the therapeutic effect,promote the improvement of thyroid function,reduce oxidative stress,and also down-regulate the levels of ICAM-1 and IGF-1,which is safe and worthy of promotion.
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