Effect of Xueshuantong combined with alteplase in the treatment of acute cerebral infarction and its influence on cerebral hemodynamics
Objective To analyze the effect of Xueshuantong combined with alteplase in the treatment of acute cerebral infarction and its influence on cerebral hemodynamics.Methods A total of 200 patients with acute cerebral infarction admitted from April 2015 to October 2021 were selected as the research objects and numbered.According to the parity of the number,the patients were divided into control group and observation group,with 100 cases in each group.The control group was treated with alteplase,and the observation group was treated with Xueshuantong on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),hematocrit(HCT)and erythrocyte sedimentation rate(ESR)in the observation group were lower than those in the control group(P<0.05).After treatment,the mean velocity(Vm)and systolic velocity(Vs)of vertebral artery(VA)and middle cerebral artery(MCA)in the observation group were higher than those in the control group,and the National Institutes of Health Stroke Scale(NIHSS)score was lower than that in the control group(P<0.05).After treatment,the levels of S-100β,endothelin-1(ET-1),soluble intercellular adhesion molecule-1(sICAM-1)and neuron-specific enolase(NSE)in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Xueshuantong combined with alteplase in the treatment of acute cerebral infarction has a good effect,it can improve the cerebral hemodynamics and hemorheology indexes of patients,and improve neurological function,which has ideal safety and important application value.
NETL
NSTL
万方数据
维普
