Effect of personalized medication regimen based on postpartum hemorrhage prediction score on prevention of postpartum hemorrhage after cesarean section and its influence on coagulation and fibrinolysis function
Objective To investigate the effect of personalized medication regimen based on postpartum hemorrhage prediction score on prevention of postpartum hemorrhage after cesarean section and its influence on coagulation and fibrinolysis function.Methods A total of 150 parturients with cesarean section admitted from June 2018 to June 2021 were selected as the research objects and randomly divided into control group and observation group,with 75 cases in each group.The control group was treated with motherwort injection,carboprost tromethamine and oxytocin,and the observation group was treated with personalized medication regimen based on postpartum hemorrhage prediction score.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).At 2 and 24 h after operation,the amount of bleeding in the observation group was less than that in the control group(P<0.05);at 3 and 7 d after operation,the uterine fundus height in the observation group was lower than that in the control group(P<0.05).At 24 h after operation,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,the level of fibrin degradation product(FDP)was lower than that in the control group,and the levels of plasminogen activator inhibitor-1(PAI-1)and antithrombin-Ⅲ(AT-Ⅲ)were higher than those in the control group(P<0.05).At 24 h after operation,the levels of catalase(CAT)and glutathione peroxidase(GSH-Px)in the observation group were higher than those in the control group,and the level of reactive oxygen species(ROS)was lower than that in the control group(P<0.05).Conclusion The personalized medication regimen based on the postpartum hemorrhage prediction score is helpful to improve the prevention effect of postpartum hemorrhage after cesarean section,reduce the amount of postpartum hemorrhage,promote the recovery of uterine fundus height,effectively improve the coagulation and fibrinolysis function,and also reduce the oxidative stress reaction,which is worthy of promotion.
postpartum hemorrhage prediction scorepersonalized medication regimencesarean sectionpostpartum hemorrhagecoagulation and fibrinolysis function
NETL
NSTL
万方数据
维普
