Clinical effect of non-invasive high-frequency oscillatory ventilation in the treatment of premature infants with neonatal respiratory distress syndrome and its influences on blood gas analysis indexes
Objective To analyze the clinical effect of non-invasive high-frequency oscillatory ventilation(nHFOV)in the treatment of premature infants with neonatal respiratory distress syndrome(NRDS)and its influences on blood gas analysis indexes.Methods A total of 120 premature infants with NRDS admitted in our hospital from January 2018 to December 2021 were selected as the research objects and divided into conventional group and observation group by random method,with 60 cases in each group.The conventional group was treated with continuous positive airway pressure ventilation,and the observation group was treated with nHFOV.The therapeutic effects of the two groups were compared.Results The duration of ventilation treatment and the length of hospitalization in the observation group were shorter than those in the conventional group,the success rate of one withdrawal was higher than that in the conventional group,and the incidences of apnea,hypercapnia,hypoxemia and bronchopulmonary dysplasia were lower than those in the conventional group(P<0.05).At 6,24 h after treatment and at the end of treatment,the blood oxygen saturation(SaO2)and partial pressure of oxygen(PaO2)in the observation group were significantly higher than those in the conventional group,and the arterial carbon dioxide partial pressure(PaCO2)and total carbon dioxide(TCO2)in the observation group were significantly lower than those in the conventional group(P<0.05).At 6,24 h after treatment and at the end of treatment,the inhaled oxygen concentration(FiO2)and mean arterial pressure(MAP)in the observation group were higher than those in the conventional group,and the oxygenation index(P/F)was lower than that in the conventional group(P<0.05).After treatment,the levels of interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the conventional group(P<0.05).Conclusion The nHFOV in the treatment of NRDS premature infants can achieve ideal therapeutic effect,reduce the incidence of adverse events,and rapidly improve arterial blood gas,oxygenation indexes and inflammation indexes.
non-invasive high-frequency oscillatory ventilationneonatal respiratory distress syndromeblood gas analysis index
NETL
NSTL
万方数据
维普
