Application value of liver-specific contrast agent MR scan combined with tumor abnormal protein,alpha-fetoprotein and alpha-fetoprotein-L3 in the diagnosis of hepatitis B-related hepatocellular carcinoma
Objective To investigate the application value of liver-specific contrast agent MR scan combined with tumor abnormal protein(TAP),alpha-fetoprotein(AFP)and alpha-fetoprotein-L3(AFP-L3)in the diagnosis of hepatitis B-related hepatocellular carcinoma(HCC).Methods Sixty-two patients with hepatitis B-related HCC were included in HCC group and 53 patients with benign liver disease were included in benign liver disease group.The TAP,AFP and AFP-L3 of the two groups were detected,and the AFP-L3/AFP(AFP-L3%)was calculated.The patients underwent upper abdominal MR plain scan and liver-specific contrast-enhanced scan,and the MR imaging findings of the two groups were analyzed.The receiver operating characteristic(ROC)curve was drawn,and the diagnostic value of MR scan,TAP,AFP,AFP-L3%alone and combined detection for hepatitis B-related HCC were discussed.Results The TAP,AFP and AFP-L3%in the HCC group were significantly higher than those in the benign liver disease group,and the differences were statistically significant(P<0.05).ROC curve showed that the area under the curve(AUC)of MR scan,TAP,AFP,AFP-L3%alone and combined detection of hepatitis B-related HCC were 0.904,0.742,0.772,0.826 and 0.931,respectively.The diagnostic efficiency of combined detection was the highest.Conclusion Liver-specific contrast agent MR scan combined with TAP,AFP,AFP-L3%detection has important clinical value for the diagnosis of hepatitis B-related HCC.
NETL
NSTL
万方数据
维普
