Meta-analysis of the efficacy of ultrasound-guided fluid resuscitation for septic shock
Objective To compare the application effects of ultrasound-guided fluid resuscitation and early goal-directed therapy(EGDT)in septic shock using Meta-analysis.Methods PubMed,Ovid,Scopus,Embase,Cochrane Library,Web of Science,China national knowledge infrastructure(CNKI),Wanfang data knowledge service platform(WANFANG),Chinese biomedical literature database(CBM),VIP Chinese scitech journal full-text database(VIP),China clinical trial data center and ClinicalTrials.gov were searched by computer.Randomized controlled trial(RCT)comparing the efficacy of ultrasound-guided fluid resuscitation and EGDT in septic shock were collected from inception to October 23,2022.Meta-analysis was performed using Review Manager5.3 statistical software.Results A total of 8 articles were included,including 482 patients with septic shock,and 3 articles had low risk bias.The results of Meta-analysis showed that there were no significant differences in lactate clearance rate(LCR)between the two groups at 6,12 and 24 h,incidence of acute kidney injury(AKI)and 28 d mortality(P>0.05);the total amount of 24 h resuscitation fluid and 24 h net fluid balance in the experimental group were lower than those in the control group(P<0.00001);the incidence of tissue edema in the experimental group was lower than that in the control group(P=0.001);the urine volume per hour after 6 h of treatment in the experimental group was more than that in the control group(P<0.00001);the mechanical ventilation time and ICU hospitalization time in the experimental group were shorter than those in the control group,and the differences were statistically significant(P=0.009,0.002).Conclusion Ultrasound-guided fluid resuscitation for septic shock can reduce the total amount of 24 h resuscitation fluid and the incidence of tissue edema,increase the urine volume per hour after 6 h of treatment,and shorten the mechanical ventilation time and ICU hospitalization time.
万方数据
维普
