临床医学研究与实践2024,Vol.9Issue(4) :122-125.DOI:10.19347/j.cnki.2096-1413.202404029

自拟化瘀涤痰汤联合依达拉奉治疗急性缺血性脑卒中的临床效果及对中医证候评分的影响

Clinical effect of self-made Huayu Ditan decoction combined with edaravone in the treatment of acute ischemic stroke and its influence on TCM syndrome score

齐爱军 景永刚 高俊丽
临床医学研究与实践2024,Vol.9Issue(4) :122-125.DOI:10.19347/j.cnki.2096-1413.202404029

自拟化瘀涤痰汤联合依达拉奉治疗急性缺血性脑卒中的临床效果及对中医证候评分的影响

Clinical effect of self-made Huayu Ditan decoction combined with edaravone in the treatment of acute ischemic stroke and its influence on TCM syndrome score

齐爱军 1景永刚 2高俊丽3
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作者信息

  • 1. 陕西省第二人民医院,陕西 西安,710005
  • 2. 陕西省彬州市人民医院,陕西 咸阳,713500
  • 3. 汉中市中心医院,陕西 汉中,723000
  • 折叠

摘要

目的 分析自拟化瘀涤痰汤联合依达拉奉治疗急性缺血性脑卒中的临床效果及对中医证候评分的影响.方法 以 2020 年 1 月至 12 月收治的 40 例急性缺血性脑卒中患者为研究对象,随机将其分为常规组(20例,依达拉奉治疗)和联合组(20 例,自拟化瘀涤痰汤联合依达拉奉治疗).比较两组的治疗效果.结果 联合组的治疗总有效率显著高于常规组(P<0.05).治疗后,联合组的各项中医证候评分均显著低于常规组(P<0.05).治疗后,联合组的神经元特异性烯醇化酶(NSE)、S-100B蛋白、缺血修饰蛋白(IMA)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平均显著低于常规组(P<0.05).治疗后,联合组的全血高切黏度、全血低切黏度、血浆黏度均显著低于常规组(P<0.05).结论 自拟化瘀涤痰汤联合依达拉奉治疗急性缺血性脑卒中可取得理想效果.

Abstract

Objective To analyze the clinical effect of self-made Huayu Ditan decoction combined with edaravone in the treatment of acute ischemic stroke and its influence on TCM syndrome score.Methods Forty patients with acute ischemic stroke admitted from January to December 2020 were selected as the study objects and randomly divided into conventional group(20 cases,edaravone treatment)and combined group(20 cases,self-made Huayu Ditan decoction combined with edaravone treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was significantly higher than that in the conventional group(P<0.05).After treatment,the TCM syndrome scores of the combined group were significantly lower than those of the conventional group(P<0.05).After treatment,the levels of neuron-specific enolase(NSE),S-100B protein,ischemia modified albumin(IMA),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)in the combined group were significantly lower than those in the conventional group(P<0.05).After treatment,whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the combined group were significantly lower than those in the conventional group(P<0.05).Conclusion The self-made Huayu Ditan decoction combined with edaravone in the treatment of acute ischemic stroke can achieve ideal effect.

关键词

急性缺血性脑卒中/自拟化瘀涤痰汤/依达拉奉

Key words

acute ischemic stroke/self-made Huayu Ditan decoction/edaravone

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基金项目

陕西省卫生健康科研基金项目(2021B002)

出版年

2024
临床医学研究与实践

临床医学研究与实践

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