Objective To investigate the effect of high-dose levothyroxine sodium tablets in the treatment of pregnancy with hypothyroidism.Methods A total of 200 patients with pregnancy with hypothyroidism admitted from November 2016 to November 2021 were selected as the research objects and randomly divided into group A and group B,with 100 cases in each group.The group A was treated with low-dose levothyroxine sodium tablets,and the group B was treated with high-dose levothyroxine sodium tablets.The therapeutic effects of the two groups were compared.Results After treatment,the thyroid length in the group B was shorter than that in the group A,thyroid peroxidase antibody(TPOAb)and thyroid stimulating hormone(TSH)levels in the group B were lower than those in the group A,and the free thyroxine(FT4)level was higher than that in the group A(P<0.05).There was no significant difference in the total incidence of pregnancy outcomes between the two groups(P>0.05).After treatment,the level of high-density lipoprotein cholesterol(HDL-C)in the group B was higher than that in the group A,and the levels of triglyceride(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)were lower than those in the group A(P<0.05).After treatment,the folic acid level in the group B was higher than that in the group A(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion High-dose levothyroxine sodium tablets in the treatment of patients with pregnancy with hypothyroidism has a better effect.It can significantly improve thyroid function and abnormal lipid metabolism,which is conducive to improving pregnancy outcomes,and the overall safety is good.
关键词
左甲状腺素钠片/大剂量/妊娠合并甲状腺功能减退症/血脂代谢/妊娠结局/甲状腺功能
Key words
levothyroxine sodium tablet/high-dose/pregnancy with hypothyroidism/blood lipid metabolism/pregnancy outcome/thyroid function
维普
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