Research progress of in vitro anticoagulation of nafamostat mesylate
In vitro anticoagulation is the addition of blood anticoagulant in the extracorporeal circulation to prevent blood coagulation in the tubing and filters.The selection of anticoagulant is an important part of the smooth implementation of in vitro anticoagulation.The current anticoagulants,such as heparin,low molecular weight heparin(LMWH),citrate,etc.,are not suitable for high-risk patients,and are prone to bleeding,thrombosis and other complications,which are not easy to master.As a new anticoagulant,nafamostat mesilate(NM)has the advantages of wide indications and fewer complications in many clinical experiments abroad,but there are few reports on NM in anticoagulation in China.This article reviews the clinical application of NM in vitro anticoagulation.
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