Expression level of GATA1 in synovial tissue of rheumatoid arthritis and its correlation with MMPs
Objective To investigate the expression level of GATA1 in synovial tissue of rheumatoid arthritis(RA)and its correlation with matrix metalloproteinase(MMPs).Methods A total of 97 patients with RA who underwent joint replacement were included in observation group,and 35 patients who underwent joint replacement or amputation due to trauma were included in control group.The expression levels of GATA1,matrix metalloproteinase-1(MMP-1),matrix metalloproteinase-3(MMP-3),matrix metalloproteinase-9(MMP-9)and matrix metalloproteinase-13(MMP-13)in synovial tissue were compared between the two groups;the correlation between the inflammatory infiltration of RA synovial tissue and the levels of GATA1,MMP-1,MMP-3,MMP-9 and MMP-13 was analyzed;the correlation between GATA1 and MMP-1,MMP-3,MMP-9,MMP-13 levels in synovial tissue of RA patients was analyzed.Results The levels of GATA1,MMP-1,MMP-3,MMP-9 and MMP-13 in synovial tissue of the observation group were higher than those of the control group(P＜0.05).There were 41 patients with low-grade synovitis and 56 patients with high-grade synovitis;the levels of GATA1,MMP-1,MMP-3,MMP-9 and MMP-13 in synovial tissue of the patients with high-grade synovitis were higher than those of the patients with low-grade synovitis(P＜0.05).The level of GATA1 in synovial tissue of RA patients was positively correlated with the levels of MMP-1,MMP-3,MMP-9 and MMP-13(P＜0.05).Conclusion GATA1 is highly expressed in RA synovial tissue,which is closely related to the degree of tissue inflammatory infiltration.It may be involved in the pathogenesis and development of RA by upregulating the expression of MMP-1,MMP-3,MMP-9 and MMP-13.
万方数据
维普
