Effect of invasive mechanical ventilation and nasal high-flow oxygen humidification sequential therapy in the treatment of elderly patients with severe pneumonia with respiratory failure and its influences on blood gas analysis indexes,HMGB1 and IL-17
Objective To explore the effect of invasive mechanical ventilation and nasal high-flow oxygen humidification sequential therapy in the treatment of elderly patients with severe pneumonia with respiratory failure and its influences on blood gas analysis indexes,high mobility group box 1 protein(HMGB1)and interleukin-17(IL-17).Methods A total of 150 elderly patients with severe pneumonia with respiratory failure admitted in our hospital from January 2021 to January 2022 were selected as the research objects,the patients were divided into control group and observation group according to the treatment methods,with 75 cases in each group.The control group was treated with invasive mechanical ventilation,and the observation group was treated with nasal high-flow oxygen humidification sequential therapy.The therapeutic effects of the two groups were compared.Results The mechanical ventilation time and respiratory intensive care unit(RICU)stay time in the observation group were shorter than those in the control group,and the reintubation rate and the incidence of ventilator associated pneumonia(VAP)were lower than those in the control group(P＜0.05).After treatment,the partial pressure of carbon dioxide(PaCO2)in the observation group was lower than that in the control group,and the pressure of oxygen(PaO2)and oxygen saturation(SaO2)were higher than those in the control group(P＜0.05).After treatment,the levels of HMGB1 and IL-17 in the observation group were lower than those in the control group(P＜0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and FEV1/FVC in the observation group were higher than those in the control group(P＜0.05).Conclusion The nasal high-flow oxygen humidification sequential therapy is more effective than invasive mechanical ventilation in the treatment of elderly patients with severe pneumonia with respiratory failure.It can not only effectively improve the blood gas analysis indexes,but also regulate the levels of HMGB1 and IL-17,and promote the recovery of lung function.
万方数据
维普
