Research progress in receptor tyrosine kinase signaling pathway mediating endocrine resistance in breast cancer
Hormone receptor(HR)-positive breast cancer is the most common subtype of breast cancer,and its main treatment is endocrine therapy.While endocrine therapy has considerably reduced recurrence rate and mortality of breast cancer,congenital or acquired resistance to this treatment is a significant clinical problem.An increasing number of mechanisms of endocrine resistance have been reported,including the adaptive upregulation of alternate signaling pathway,such as receptor tyrosine kinase(RTK)signaling pathway and the interaction between estrogen receptor(ER)and RTK signaling pathways.Based on this,this article reviews the latest progress in the mechanism of RTK signaling pathway mediating endocrine resistance in HR-positive breast cancer.
breast cancerhormone receptorendocrine resistancereceptor tyrosine kinase
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