Effect of fasudil hydrochloride combined with low molecular weight heparin calcium on coagulation function in patients with ischemic stroke
Objective To explore the effect of fasudil hydrochloride combined with low molecular weight heparin calcium on coagulation function in patients with ischemic stroke.Methods A total of 120 patients with ischemic stroke admitted from July 2018 to October 2021 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with low molecular weight heparin calcium,and the observation group was treated with fasudil hydrochloride on the basis of the treatment regimen of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of D-dimer(D-D)and fibrinogen(FIB)were lower than those in the control group,and the prothrombin time(PT)and thrombin time(TT)in the observation group were longer than those in the control group(P<0.05).After treatment,the mean blood flow velocity of bilateral middle cerebral artery(MCA),anterior cerebral artery(ACA),posterior cerebral artery(PCA)and bilateral vertebral artery(VA)in the observation group were higher than those in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the observation group was lower than that of the control group,and the Modified Barthel Index(MBI)score was higher than that of the control group(P<0.05).Conclusion Fasudil hydrochloride combined with low molecular weight heparin calcium can improve cerebral hemodynamics and coagulation function in patients with ischemic stroke,promote the recovery of neurological function,and help to improve their daily living ability.
low molecular weight heparin calciumfasudil hydrochlorideischemic strokecoagulation functionneurological function
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维普
