Effect of early lateral ventricle drainage combined with aneurysm interventional embolization in the treatment of aneurysmal subarachnoid hemorrhage and its influences on sICAM-1 and Caspase-3
Objective To explore the effect of early lateral ventricle drainage combined with aneurysm interventional embolization in the treatment of aneurysmal subarachnoid hemorrhage(aSAH).Methods A total of 100 patients with aSAH received from January 2017 to December 2021 were selected as the research objects.According to different treatment plan,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with aneurysm interventional embolization,and the observation group was treated with early lateral ventricle drainage on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).At 7 d after operation,the levels of soluble intercellular adhesion molecule-1(sICAM-1)and cysteinyl aspartate specific proteinase-3(Caspase-3)in the observation group were lower than those in the control group(P<0.05).At 7 d after operation,the minimum blood flow velocity(Vmin)and dynamic resistance(DR)in the observation group were higher than those in the control group,and the vascular resistance(RV)and pulse wave velocity(Wv)were lower than those in the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Early lateral ventricle drainage combined with aneurysm interventional embolization in the treatment of aSAH can improve the cerebral hemodynamics of patients,regulate the levels of sICAM-1 and Caspase-3,reduce the incidence of complications,and improve the overall efficacy,which is worthy of promotion.
early lateral ventricle drainageaneurysm interventional embolizationaneurysmal subarach-noid hemorrhage
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