Effect of citalopram combined with pantoprazole and itopride in the treatment reflux esophagitis and its influence on clinical symptoms of patients
Objective To analyze the effect of citalopram combined with pantoprazole and itopride in the treatment of reflux esophagitis(RE).Methods A total of 100 patients with RE admitted in our hospital from March 2020 to March 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 50 cases in each group.Both groups of patients given symptomatic treatment during hospitalization,on this basis,the control group was treated with pantoprazole and itopride,and the observation group was treated with citalopram combined with pantoprazole and itopride.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of motilin in the observation group was higher than that in the control group,and the levels of gastrin and interleukin-17(IL-17)were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of acid reflux,retrosternal burning pain and heartburn in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Citalopram combined with pantoprazole and itopride in the treatment of RE has achieved ideal application effect,which can alleviate the anxiety and depression of patients,reduce the influence of psychological factors on the treatment,improve the clinical efficacy,significantly ameliorate the clinical symptoms,and has high drug safety,which is worthy of clinical promotion.
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