Effect of sacubitril valsartan combined with trimetazidine on ventricular remodeling indexes in patients with myocardial infarction after PCI
Objective To explore the effect of sacubitril valsartan combined with trimetazidine in the treatment of myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 108 patients with myocardial infarction after PCI admitted in our hospital from May 2019 to December 2021 were selected as the research objects.According to the different postoperative treatment plan,the patients were divided into control group and observation group,with 54 cases in each group.The control group was treated with trimetazidine on the day after PCI,and the observation group was treated with sacubitril valsartan on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the interventricular septal thickness(IVST),left ventricular mass index(LVMI)and left ventricular mass(LVM)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the proportion of grade Ⅱ in thrombolysis in myocardial infarction(TIMI)and TIMI myocardial perfusion grade(TMPG)in the observation group were lower than those in the control group,and the proportion of grade Ⅲ were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF),and early diastolic maximum peak velocity/late diastolic maximum peak velocity(E/A)of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The sacubitril valsartan combined with trimetazidine in the treatment of patients with myocardial infarction after PCI has a better effect,which can improve myocardial perfusion,relieve ventricular remodeling and promote the recovery of cardiac function.
sacubitril valsartantrimetazidinemyocardial infarctionpercutaneous coronary interventionventricular remodelingcardiac function
万方数据
维普
