Effect of aspirin combined with low-dose ticagrelor on the prevention and treatment of thrombosis after PCI in patients with coronary heart disease and its influences on cardiac function and coagulation function
Objective To analyze the effect of aspirin combined with low-dose ticagrelor on the prevention and treatment of thrombosis after percutaneous coronary intervention(PCI)in patients with coronary heart disease and its influences on cardiac function and coagulation function.Methods A total of 112 patients with coronary heart disease who underwent PCI were selected as the research objects.According to different postoperative treatment methods,the patients were divided into clopidogrel(LBGL)group(n=32),ticagrelor standard dose(TGRL-S)group(n=40)and ticagrelor low dose(TGRL-L)group(n=40).The therapeutic effects of the three groups were compared.Results At 6 months after operation,the microcirculation resistance index(MRI),coronary flow reserve fraction(CFR)and left ventricular ejection fraction(LVEF)in the TGRL-S group and TGRL-L group were better than those in the LBGL group(P<0.05).At 6 months after operation,the maximum platelet aggregation rate and fibrinogen(FIB)level in the TGRL-S group and the TGRL-L group were lower than those in the LBGL group(P<0.05).At 1 year after operation,the proportion of stent lumen diameter<30% in the TGRL-S group and the TGRL-L group were higher than those in the LBGL group(P<0.05);the total incidence of major adverse cardiovascular events(MACE)was lowest in the TGRL-L group,followed by the TGRL-S group,and highest in the LBGL group(P<0.05).Conclusion Aspirin combined with low-dose ticagrelor can significantly improve cardiac function and coagulation function after PCI for coronary heart disease,with a lower incidence of MACE and high safety,which is worthy of promotion.
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