Application effect of early enteral and parenteral nutrition support in neonatal hypoxie-ischemic encephalopathy and its influence on NBNA score
Objective To explore the application effect of early enteral and parenteral nutrition support in neonatal hypoxie-ischemic encephalopathy(HIE)and its influence on Neonatal Behavioral Neurological Assessment(NBNA)score.Methods A total of 124 children with HIE admitted from January 2016 to December 2021 were selected as the research objects and divided into control group and study group according to the random number table method,with 62 cases in each group.The control group received parenteral nutrition support treatment,and the study group received enteral + parenteral nutrition support treatment.The therapeutic effects of the two groups were compared.Results The oral intake time,time to reach basic calorie and hospitalization time of the study group were shorter than those of the control group,and the weight gain value after 15 d of treatment was higher than that in the control group(P<0.05).After treatment,the levels of indirect bilirubin and direct bilirubin in the study group were lower than those in the control group,and the levels of chloride ion and calcium ion were higher than those in the control group(P<0.05).After treatment,the levels of 8-hydroxy-2'-deoxyguanosine(8-OHdG),neuron specific enolase(NSE)and soluble interleukin-2 receptor(sIL-2R)in the study group were lower than those in the control group,the levels of insulin-like growth factor-1(IGF-1)and interleukin-2(IL-2)were higher than those in the control group(P<0.05).The total incidence of complications in the study group was lower than that in the control group(P<0.05).After 5,10 and 15 d of treatment,the NBNA score of the study group was higher than that of the control group(P<0.05).Conclusion Early enteral and parenteral nutrition support applied in the treatment of HIE can shorten the hospitalization time of children,help to promote the prognosis of the disease,and has positive significance for improving the prognosis.
neonatalhypoxie-ischemic encephalopathyearly enteral and parenteral nutritionelectrolyte
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