Clinical effect of different doses of gamma globulin in the treatment of Kawasaki disease in children
Objective To analyze the clinical effect of different doses of gamma globulin in the treatment of Kawasaki disease in children.Methods The data of 68 children with Kawasaki disease admitted in our hospital from March 2020 to March 2022 were reviewed.All children were treated with gamma globulin on the basis of conventional aspirin.According to the dose of gamma globulin,the children were divided into low-dose group(34 cases,treated with 1.0 g/kg gamma globulin)and high-dose group(34 cases,treated with 2.0 g/kg gamma globulin).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the high-dose group was higher than that in the low-dose group(P<0.05).The elimination time of fever,mucosal diffuse congestion,trunk erythema,cervical lymph node swelling and throat congestion in the high-dose group were shorter than those in the low-dose group(P<0.05).After treatment,the thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)in the high-dose group were longer than those in the low-dose group,and the fibrinogen(FIB)level was lower than that in the low-dose group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)and white blood cell(WBC)in the high-dose group were lower than those in the low-dose group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The high-dose gamma globulin in the treatment of Kawasaki disease in children has a good effect and high safety,which is worthy of promotion.
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