Objective To analyze the effects of different doses of dexmedetomidine on surgical outcome and myocardial injury in patients undergoing cardiac valve replacement with cardiopulmonary bypass(CPB).Methods A total of 202 patients undergoing cardiac valve replacement with CPB in our hospital from January to December 2021 were selected as the research objects,and the patients were divided into 0.2 μg group(101 cases,0.2 μg dexmedetomidine)and 0.4 μg group(101 cases,0.4 μg dexmedetomidine)according to the dose of dexmedetomidine.The anesthetic effects of the two groups were compared.Results There were no significant differences in CPB duration,aortic occlusion duration and automatic heart resuscitation rate between the two groups(P>0.05).Before and after operation,there were no significant differences in the levels of brain natriuretic peptide(BNP),creatine kinase MB(CK-MB),cardiac troponin T(cTnT),soluble growth stimulation expressed gene 2 protein(sST2)and heart-type fatty acid binding protein(hFABP)between the two groups(P>0.05).There were no significant differences in the incidences of intraoperative bradycardia,hypotension,respiratory depression and postoperative dizziness between the two groups(P>0.05);the incidence of postoperative nausea and vomiting and cognitive impairment in the 0.4 μg group were significantly higher than those in the 0.2 μg group(P<0.05).Conclusion The use of 0.2 μg dexmedetomidine for surgical anesthesia in patients undergoing cardiac valve replacement with CPB can achieve better surgical prognosis.
维普
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