Effect of vitamin A palmitate eye gel combined with sodium hyaluronate eye drops in the treatment of dry eye disease and its influences on ocular surface function and quality of life of patients
Objective To analyze the effect of vitamin A palmitate eye gel combined with sodium hyaluronate eye drops in the treatment of dry eye disease and its influences on ocular surface function and quality of life of patients.Methods A total of 116 patients with dry eye disease admitted in our hospital from August 2021 to January 2022 were randomly divided into routine group(58 cases,sodium hyaluronate eye drops)and observation group(58 cases,vitamin A palmitate eye gel combined with sodium hyaluronate eye drops).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the routine group(P<0.05).After treatment,the score of Ocular Surface Disease Index(OSDI)in the observation group was significantly lower than that in the routine group,and the score of National Eye Institute Visual Related Quality of Life Scale-25(NEI-VFQ-25)was significantly higher than that of the routine group(P<0.05).After treatment,the break-up time(BUT),corneal fluorescence staining(CFS)score and schirmer Ⅰ test(SⅠT)of the observation group were significantly better than those of the routine group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),matrix metalloproteinase-9(MMP-9),matrix metalloproteinase-2(MMP-2),interleukin-6(IL-6)and interleukin-1β(IL-1β)in the observation group were significantly lower than those in the routine group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05);the recurrence rate within half a year in the observation group was significantly lower than that in the routine group(P<0.05).Conclusion The vitamin A palmitate eye gel combined with sodium hyaluronate eye drops in the treatment of dry eye disease can achieve ideal effect.
dry eye diseasevitamin A palmitate eye gelsodium hyaluronate eye drops
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