A case of uterine tumor resembling ovarian sex cord tumor and literature review
Objective To investigate the clinical and histopathological features,diagnosis and differential diagnosis of uterine tumor resembling ovarian sex cord tumor(UTROSCT).Methods The clinical data of 1 case of UTROSCT were analyzed,the histomorphology and immunohistochemistry were tested,and the related literature were reviewed.Results The UTROSCT cells are arranged in trabecular and nest shape,infiltrating the surrounding smooth muscle tissue.Some tumor cells were epithelioid,eosinophilic in cytoplasm,and some tumor cells were translucent or foamy in cytoplasm,the nuclei were round,oval and short spindle,the chromatin was delicate,the nuclear groove was visible,and some nucleoli were significant.There were no mitotic image,intravascular tumor thrombus and necrosis.Immunohistochemistry showed that cytokeratin(CK),calretinin(CR),CD99,inhibin-A,steroidogenic factor-1(SF-1),wilms tumor gene-1(WT-1),estrogen receptor(ER)and progesterone receptor(PR)were positive;melanoma antigen recognized by T cells 1(Melan-A),S100 and desmin were focally positive;carcinoembryonic antigen(CEA),epithelial membrane antigen(EMA),multiple tumor suppressor 1(MTS/P16),melanoma marker(HMB45),smooth muscle actin(SMA),CD10 and CD34 were negative;Ki67 proliferation index was about 1%positive.Conclusion UTROSCT is a rare type of uterine tumor with the characteristics of ovarian sex cord stromal tumor.The clinical symptoms and imaging examination are lack of specificity,and the diagnosis depends on postoperative histomorphology and immunohistochemistry.Its biological behavior has low malignant potential,most of which are benign processes and need long-term follow-up.
uterine tumor resembling ovarian sex cord tumorclinicopathological featureimmunohisto-chemistry
万方数据
维普
