Clinical rational application and management countermeasures of non-ionic iodine contrast agent
Objective To analyze the imaging effects and adverse reactions of non-ionic iodine contrast agent with different concentrations and injection rates in CT examination,and provide basis for the correct selection of drugs,scanning schemes and adverse reactions in clinical CT examination.Methods A total of 12 500 patients with non-ionic iodine contrast agent were randomly selected.According to the three commonly used contrast agent use patterns,the patients were divided into group A(2 780 cases),group B(6 230 cases)and group C(3 490 cases).The group A was treated with iopamidol 370 mg/L at a rate of 5 mL/s;the group B was treated with iohexol 300 mg/L at a rate of 3 mL/s;the group C was treated with iodixanol 270 mg/L at a rate of 2.5 mL/s.The image quality,contrast agent leakage and adverse reactions of the three groups were compared.Results The image quality of the three groups of patients was unqualified in 153 cases,accounting for 1.22%(153/12 500);the image quality was qualified in 12 347 cases,accounting for 98.78%(12 347/12 500).There was no significant difference in the qualified rate of image quality among the three groups(P>0.05).There were 25 cases of contrast agent leakage in the three groups,with an incidence of 0.20%(25/12 500).There were 17 cases of contrast agent leakage in the group A,with an incidence of 0.61%(17/2 780);there were 7 cases of contrast agent leakage in the group B,and the incidence rate was 0.11%(7/6 230);there was 1 case of contrast agent leakage in the group C,and the incidence rate was 0.03%(1/3 490);there was a statistically significant difference in the incidence of contrast agent leakage among the three groups(P<0.005).There were 97 cases of adverse reactions in the three groups,accounting for 0.78%(97/12 500),including 84 cases of mild reactions,accounting for 0.67%(84/12 500);13 cases of moderate reactions,accounting for 0.10%(13/12 500);and no severe adverse reactions.The total incidence of adverse reactions in the three groups was statistically significant(P<0.005);the total incidence of adverse reactions in the group B was lower than that in the group A,and the difference was statistically significant(P<0.05).Conclusion Prevention and treatment of the application risk of non-ionic iodine contrast agent is a very important issue in CT scan.Analysis from the aspects of risk prevention of adverse reactions of non-ionic iodine contrast agent,risk prevention and nursing of contrast agent leakage can ensure the safety of patients while ensuring the best image effect.
万方数据
维普
