Influences of dexmedetomidine combined with ultrasound-guided thoracic paravertebral nerve block on anesthesia effect and cognitive function in patients undergoing thoracoscopic radical resection of lung cancer
Objective To investigate the influences of dexmedetomidine combined with ultrasound-guided thoracic paravertebral nerve block on anesthesia effect and cognitive function in patients undergoing thoracoscopic radical resection of lung cancer.Methods A total of 100 patients undergoing thoracoscopic radical resection of lung cancer from January 2019 to January 2022 were selected as the research objects.According to the difference of anesthesia methods,the patients were divided into control group and observation group,with 50 cases in each group.The control group was given ropivacaine for ultrasound-guided thoracic paravertebral nerve block,and the observation group was given dexmedetomidine on the basis of the control group.The anesthetic effects of the two groups were compared.Results At 5 min after intubation(T1),30 min after operation(T2)and at the end of operation(T3),the heart rate(HR),mean arterial pressure(MAP)and 5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2),adrenocorticotrophic hormone(ACTH)levels in the observation group were lower than those in the control group(P<0.05).At postoperative 6 h(T5),postoperative 12 h(T6),postoperative 24 h(T7)and postoperative 48 h(T8),the Visual Analogue Scale(VAS)score of the observation group was lower than that of the control group(P<0.05).At 1 d after operation,the scores of Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)in the observation group were higher than those in the control group(P<0.05).Conclusion Dexmedetomidine combined with ultrasound-guided thoracic paravertebral nerve block can improve the anesthetic effect of patients undergoing thoracoscopic radical resection of lung cancer,maintain hemodynamic stability,reduce intraoperative and postoperative pain,and the impact on cognitive function.
dexmedetomidinethoracic paravertebral nerve blockradical resection of lung canceranes-thesiacognitive function
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